DAXX, MEN1, PREX2, CDKN1B, GLI2, and HRAS mutations were more frequent among men with PNETs compared to women, whereas NRTK1, SPOP mutations were identified with more frequency among women (all p<0.05 by FE). However, this phenomenon appears to have arisen due to survival differences among patients with early stage disease and survival rates were similar among men and women who have stage 3 or 4 disease (stage 1: 88.2 % vs. 5-year survival was worse for men than women (80.7, 95%-CI % vs. Despite this, rates of lymph node positivity (29.1% vs. Men more frequently had tumors > 2 cm than women (65.3% vs 60.1%, p<0.001) and more commonly had poorly or undifferentiated tumors (5.7% vs. Results: 15,196 patients met inclusion criteria for analysis from the NCDB 7,890 (51.9%) were men and 7,306 (48.1%) were women. Frequencies of mutational signatures were compared by Fischer's exact (FE) test, adjusting for multiple testing via the Benjamini-Hochberg correction. Sex-based differences in PNET mutational signatures were analyzed by querying the open access dataset of patients whose tumor genomic data was submitted to the American Association for Cancer Research Genomics Evidence Neoplasia Information (AACR-GENIE) Cohort v10.1-public. The overall survival of men and women by stage of disease was compared using Kaplan-Meier method. Clinicopathologic features were analyzed by sex. Methods: The National Cancer Database (NCDB) was queried for PNET patients diagnosed 2004-2017 who underwent surgical intervention. We aimed to further characterize sex-based clinicopathologic and survival differences and divergences in mutational signatures among patients with PNETs.
#Rasa zarnegar drivers#
Among patients with PNETs, sex-specific transcriptional differences have been identified, as have mutational drivers with known prognostic significance. However, mechanisms driving these differences remain poorly understood. Introduction: Sex-based differences in survival trends have emerged among patients with pancreatic neuroendocrine tumors (PNETs). Min Surgery, Weill Cornell Medicine, New York, NY Ivanov, Caitlin Egan, Yeon Joo Lee, Rasa Zarnegar, Thomas J. SEX-BASED CLINICOPATHOLOGIC AND SURVIVAL DIFFERENCES AMONG PATIENTS WITH PANCREATIC NEUROENDOCRINE TUMORS
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